Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical GSK1070916, Purity: ≥98%, CAS: 942918-07-2, 1 mg
A potent inhibitor of Aurora B and C (Kis = 0.38 and 1.5 nM, respectively); >250-fold selective for Aurora B and C over Aurora A; inhibits proliferation of A549 lung cancer cells in vitro (EC50 = 7 nM); inhibits proliferation in a panel of 100 tumor cell lines (EC50s = <10 nM); inhibits histone H3 phosphorylation in a COLO 205 mouse xenograft model and induces tumor regression in an HL-60 mouse xenograft model; reduces tumor growth in 10 mouse xenograft models
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TARGETMOL CHEMICALS INC ESUPRONE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Esuprone (LU-43839) is a novel reversible and highly selective MAO-A inhibitor with anticonvulsant activity for the treatment of depression. purity: 99%
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Cayman Chemical SR 48692, Purity: ≥98%, CAS: 146362-70-1, 5 mg
An allosteric antagonist of NTS1 (Kd = 3.4 nM); inhibits neurotensin binding to brain tissue from guinea pig, newborn mouse, newborn human, and adult human as well as rat mesencephalic cells and HT-29 cells (IC50s = 0.99-30.3 nM); blocks neurotensin induced intracellular calcium mobilization in HT-29 cells (Ki = 7.4 nM); reduces tumor volume and cell proliferation in an NCI-H209 mouse xenograft model (10 μg per day); reduces contralateral turning induced by neurotensin administration in mice by 85% (80 μg/kg, p.o.); delays sensitization to the locomotor activating effects of cocaine in rats when administered prior to cocaine delivery and not concomitantly
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Medchemexpress LLC Recombinant human SIRT5 (N-Flag) | >95.0% | 10 UG
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Recombinant human SIRT5 (N-Flag) is a lyophilized, E. coli-expressed full-length human SIRT5 protein intended for research use. It contains an N-terminal Flag tag, shows >95% purity by reducing SDS-PAGE, and has an approximate molecular weight of 33-37 kDa. Follow manufacturer instructions for reconstitution and storage.
- Supplied as lyophilized powder for long-term storage.
- N-terminal Flag tag enables detection and purification.
- Expressed in E. coli expression system.
- Purity greater than 95.0% as determined by reducing SDS-PAGE.
- Molecular weight approximately 33-37 kDa.
- Sequence covers R2-S310 of human SIRT5.
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Cayman Chemical MDA-19 4-hydroxybenzoyl metabolite, Purity: ≥98%, 5 mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; a potential metabolite of MDA-19; intended for research and forensic applications
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eMolecules 2073059-82-0 | Medchem Express | SBI-993 | 5mg | 742367576 | HY-122682 | 452.53 | C23H24N4O4S
Ambeed | 4H-Cyclopenta[12-b54-b]dithiophene | 250mg | 552594338 | A154879 | 389-58-2 | MFCD20133900 | 178.270 | C9H6S2
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eMolecules Building Block Tool
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Cayman Chemical 2-NP-AHD, Purity: ≥95%, CAS: 623145-57-3, 25 mg
A nitrophenyl derivative of AHD; has been used in immunoassays for the detection of AHD in honey
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Medchemexpress LLC EHT 5372 | 1425945-63-6 | 98.12% | 404.27 | 25 MG
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EHT 5372 is a potent and selective inhibitor of DYRK's family kinases, demonstrating high inhibitory activity against DYRK1A and DYRK1B. It also shows inhibitory effects on DYRK2, DYRK3, CLK1, CLK2, CLK4, GSK-3α, and GSK-3β. This compound has applications in various research areas, including neurological disorders like Alzheimer's Disease, cancer, and diabetes, by reducing pS396-Tau levels and Aβ production.
- Potent and selective inhibitor of DYRK's family kinases
- Inhibits DYRK1A, DYRK1B, DYRK2, DYRK3, CLK1, CLK2, CLK4, GSK-3α, and GSK-3β
- Reduces pS396-Tau levels
- Reduces Aβ production
- Suitable for research in neurological disorders, cancer, and diabetes
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Selleck Chemical LLC Guanidine thiocyanate E4830-1G
Guanidine thiocyanate is a potent inhibitor of nucleases and a powerful denaturant of proteins It is used for RNA isolation due to its strong chaotropic properties which effectively denature RNase enzymes in samples ensuring RNA stability and purity during extraction processes Nucleic acid extraction buffers containing guanidine thiocyanate effectively deactivate high-titer polioviruses found in potentially infectious materials
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Cayman Chemical SM-324405, Purity: ≥95%, CAS: 677773-91-0, 10 mg
A TLR7 agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor); selective for TLR7 over TLR8 (EC50 = >10 µM); induces IFN production in isolated human PBMCs (MEC = 10 nM); induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively); inhibits BALF eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation
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Cayman Chemical Ruscogenin, Purity: ≥95%, CAS: 472-11-7, 5 mg
A steroid sapogenin with diverse biological activities; reduces PMA-induced adhesion of HL-60 cells to ECV304 cells (IC50 = 7.76 nM); decreases zymosan A-induced peritoneal leukocyte migration in rats at 5 mg/kg; inhibits ADP-induced platelet aggregation in rats at 12.5 mg/kg; prevents monocrotaline-induced increases in MAP, expression of IL-1β and TNF in plasma and lung, and endothelial cell apoptosis in pulmonary arterioles in a rat model of pulmonary hypertension; reduces proteinuria and renal macrophage infiltration in a rat model of streptozotocin-induced diabetes; decreases gene expression of inflammatory cytokines, dyslipidemia, and liver steatosis in a hamster model of high-fat diet-induced NASH
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Medchemexpress LLC Umbralisib | 1532533-67-7 | >98.0% | 100 MG
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Umbralisib is a selective, orally active small-molecule inhibitor of PI3Kδ and casein kinase-1-ε supplied as a solid research compound for preclinical and biochemical studies.
- Selective PI3Kδ and CK1ε inhibition suitable for signaling studies.
- High purity for biochemical and cellular assays.
- Provided as a solid formulation for convenient storage and handling.
- Available in small-scale packages for laboratory research.
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Cayman Chemical AUTEN-99, Purity: ≥98%, CAS: 1049780-58-6, 10 mg
An inhibitor of MRMR14/Jumpy; inhibits MTMR14/Jumpy activity in a cell-free assay at 10 and 100 µM; enhances autophagic flux and increases the levels of LC3B-11 in HeLa cells at 1 and 10 µM; increases survival of mouse primary neurons exposed to hydrogen peroxide as a model of oxidative stress at 0.5-5 µM; increases the number of autophagic structures in mouse pancreas, kidney, and liver; induces autophagy in the Drosophila larval fat body and increases the percentage of flies climbing a glass column in a climbing assay in a transgenic model of Parkinson’s disease
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![Medchemexpress LLC N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide | 34435-05-7 | 99.9% | C42H83NO3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260017.png-250.jpg)
Medchemexpress LLC N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide | 34435-05-7 | 99.9% | C42H83NO3 | 10MG
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C24-Ceramide is a long-chain sphingolipid (Cer(d18:1/24:0)) used in biochemical and membrane research. Supplied as a research-grade solid, it is applied in studies of membrane structure, lipid signaling, and lipid metabolism. Users should consult the supplier COA and SDS for batch-specific purity, solubility, and storage instructions.
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Medchemexpress LLC HY-112829 5mg Medchemexpress, FASN-IN-2 CAS:1399177-37-7 Purity:>98%
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Medchemexpress, HY-112829 5mg FASN-IN-2 CAS:1399177-37-7 FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor extracted from patent WO2012122391A1, compound 152, has an IC 50 of 0.052 μM and an EC 50 of 0.072 μM [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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